Whereas feminist theory has revitalized our understanding of the culture of medieval Europe, gay theory has only recently begun to review and rewrite that period of our past. Simon Gaunt, writing in 1992, offered several explanations for this state of affairs—including the homophobia of many educational institutions and a notable lack of visible gay scholars in the field. But the following explanation, I think, goes deepest, and is historically the most intractable. However much medieval women may have differed from modern (...) women, he reminds us, they are “clearly and prominently visible within [medieval] systems of representation.” Though we need to reconstruct their experience with care, since most of the records were produced by men, there is nonetheless no shortage of material. Not so for men whose desire was stirred by other men: “one of the prime difficulties in conducting research on the experience of gay people in the Middle Ages is simply lack of data. With whose experience do we identify?”. (shrink)

In 1924 W. W. Tarn published an article in which he attempted to prove that the mother of Philip V of Macedon was the Epirot princess Phthia. Previously all historians had accepted the statement of Eusebius that Philip was the son of Demetrius II and Chryseis, whom, after the death of her husband, the Macedonians gave in marriage to Antigonus Doson. Despite the cogency of Tarn's arguments, his theory has been rejected by both Beloch and Dinsmoor, who adhere to the (...) traditional view. This problem of the identity of Philip's mother is one of considerable importance, and consequently in this paper I intend to collect the evidence once again and subject it to a careful analysis. The results will be found strongly to corroborate Tarn's contention. (shrink)

Berdiaev always insisted on his exclusive closeness to Dostoevsky. He attributed to Dostoevsky the main ideas and motifs of his own philosophizing and simply called himself "Dostoevsky's son" in developing the eschatological problematic and on the question of theodicy.

SummarySon preference has been considered as a determinant of women's risk of intimate partner violence experience in India, although quantitative evidence from large nationally representative studies testing this relationship is limited. This study examines the association between husband's son preference, sex composition of children and risk of physical and sexual IPV victimization among wives. Information was collected for 26,284 couples in the nationally representative 2005–2006 National Family Health Survey of India. The exposures were husband's son preference measured as husband's desire (...) for one or more sons greater than the number of daughters and sex composition of the household: only sons, only daughters and mixed. Outcome included past year physical and/or sexual IPV. The results showed that husband's reported son preference and sex composition of children were not associated with risk for IPV victimization in the models adjusted for socio-demographic factors. The findings from this first population-based study of socio-cultural norms around son preference and married Indian women's risk for IPV victimization indicate that cultural preference for sons does not influence women's risk for IPV victimization. (shrink)

In the early morning hours of August 4, 2013, Joy Pavelich's world was shattered when she found out that her twenty-year-old son Eric had taken his own life at the family farm in Saskatchewan. Struggling to make sense of Eric's sudden and unexpected suicide, Joy takes a deeply personal and difficult journey through his past--from his happy childhood, to his mental health struggles in his early teens, to his death and the resulting aftermath of his passing. CHASING MY SON ACROSS (...) HEAVEN demonstrates how to rebuild a life fractured by extreme trauma using storytelling as a powerful healing tool. The author tackles some of the most pressing issues facing society today: youth mental health, suicide and post-traumatic stress. Through her explorations, Joy reveals how we can all find the courage to rebuild our lives while continuing to honor the deep love for those we've lost."--Back cover. (shrink)

One of the most persistent and popular bourgeois myths about Spinoza is that of his unwillingness to participate in any kind of political struggle whatever. This myth is sustained particularly by those non-Marxist historians of philosophy who contend that the essence of Spinozism is the development of a new form of religiosity, free of the limitations of any national religion. Such a conception of the Dutch thinker is partially based on facts related by his first biographers, particularly Lucas. As we (...) know, Lucas, in his Life of Benedict Spinoza, written in French between 1678 and 1688, writes that the philosopher's father, Michael de Spinoza, lacking funds and being unable to establish his son in commerce, chose for him the career of a rabbi, and with this in mind placed the young Spinoza in the Amsterdam kheder, where he gained an excellent knowledge of classical Hebrew and studied to perfection the Old Testament and the considerably more voluminous Talmud. Even during his period of instruction, Spinoza, having found many contradictions in the Bible and Talmud, placed the rabbis who were his teachers in untenable positions and this subsequently led to a conflict between him and the leadership of the Amsterdam Jewish community. This report by Spinoza's first biographer suggests the idea that the young Spinoza had crystallized his ideas as early as his stay in the kheder. This we find stated in many of the non-Marxist studies devoted to him. Soviet writings on Spinoza also usually repeat Lucas' view entirely without criticism . However, certain foreign researches of recent decades, which have given consideration to documents and firsthand reports published in 1932 by the Dutch researcher Vaz Dias and, more recently, certain other documents have necessitated considerable corrections in the biographies both by Lucas and Colerus. In these works — of which the book by the French researcher Madeleine Francés, Spinoza dans les pays Neerlandais de la seconde moitié du XVII siècle, Vol. I, Paris, 1937, and that of the American researcher, Lewis Feuer, Spinoza and the Rise of Liberalism, Boston, 1958, are particularly worthy of mention — serious attempts are made to demonstrate the social roots and essence of Spinozism. The biographical data presented in these works contribute to a clarification of the real reasons for the conflict between the young Spinoza and the leadership of the Jewish community of Amsterdam. According to these writers, Spinoza's father was a wealthy man and, in all probability, did not intend to make a rabbi of his son. There can be no question that the young Spinoza attended the elementary classes of the Jewish school, but his name is not found in the lists of students in its higher grades, from which future rabbis emerged. Beginning approximately at the age of thirteen, Bento helped his father in his commercial and financial operations. However, after his father's death, Baruch himself took charge of these matters during the period 1654-1656 and, as these documents suggest, demonstrated considerable skill in commercial and financial affairs. However, the activities of merchant and financier did not appeal to the young man. The discrepancy between his intellectual interests and the nature of his occupation proved so irreconcilable that the future philosopher, who had established numerous scholarly and personal ties outside the Jewish community, drifted farther and farther both from his business and the community, until finally he was excommunicated, and broke with the community. (shrink)

This book is a philosophical examination of the logical problems associated with the claim that Jesus of Nazareth was one and the same person as God the Son, the Second Person of the divine Trinity.

Les colonies de Terre Sainte, en dépit de trois croisades successives, ont abordé le dernier quart du 13e siècle dans un état de faiblesse inquiétant. Le pape Grégoire X a essayé durant cinq ans de redresser la situation par tous les moyens. L'A. retrace tout d'abord la destinée exceptionnelle de ce pape, de son vrai nom Tebaldo Visconti, né à Plaisance en 1210 et mort à Arezzo en 1276. Il étudie ensuite l'action de Grégoire X dans son redressement spirituel de (...) l'Orient latin. Son désir profond de venir en aide à la Terre Sainte s'exprima aussi dans des mesures financières. Les limites de l'action du Saint-Siège sont étudiées ainsi que le soutien logistique des colonies franques de Syrie apporté au pape. L'évolution de la conjoncture internationale compromit sérieusement à partir de 1273 les retombées ses efforts. (shrink)

Purpose of the article is the reconstruction of ancient Greek and ancient Roman models of religiosity as anthropological invariants that determine the patterns of thinking and being of subsequent eras. Theoretical basis. The author applied the statement of Protagoras that "Man is the measure of all things" to the reconstruction of the religious sphere of culture. I proceed from the fact that each historical community has a set of inherent ideas about the principles of reality, which found unique "universes of (...) meanings". The historical space acquires anthropological properties that determine the specific mythology of the respective societies, as well as their spiritual successors. In particular, the religious models of ancient Greece and ancient Rome had a huge influence on formation of the worldview of the Christian civilization of the West. Originality. Multiplicity of the Olympic mythology contributed to the diversity of the expression forms of the Greek genius, which manifested itself in different fields of cultural activity, not reducible to political, philosophical or religious unity. The poverty of Roman mythology was compensated by a clear awareness of the unity of the community, which for all historical vicissitudes had always remained an unchanging ideal, and which was conceived as a reflection of the unity of the heavens. These two approaches to the divine predetermined the formation of two interacting, but conceptually different anthropological paradigms of Antiquity. Conclusions. Western concepts of divinity are invariants of two basic theological concepts – "Greek" and "Roman". These are ideal types, so these two tendencies can co-exist in one society. The Roman trend continued to be realized by the anti-Roman religion, which took Roman forms and Roman name. Iconoclasm was a Byzantine version of the Reformation, promoted by the Isaurian emperors and failed due to the strong Hellenistic naturalistic lobby. Modern "Romans" are trying to get rid of the last elements of religious naturalism, and modern "Greeks" are trying to preserve the Hellenic elements in Christianity. Patterns can be transformed, but the observational view will still be able to identify their lineage. The developed model allows a deeper understanding of the culture of both ancient societies, as well as the outlook of Western man. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Closing the Gaps in Pediatric HIV/AIDS Care, One Step at a TimeLisa V. Adams, Helga Naburi, Goodluck Lyatuu, Paul Palumbo, and C. Fordham von ReynFatuma's* doctors were completely perplexed. It was 2003 and she had returned to the DARDAR clinic in her hometown of Dar es Salaam, Tanzania three times that week with vague complaints of various pains and aches. Her doctors were considering whether these symptoms were due (...) to the initiation of her recent treatment with antiretroviral medications for her HIV infection or related to the last administration of the investigational tuberculosis (TB) vaccine that the DARDAR Health Study was evaluating. Fatuma's doctor, Dr. Lillian Mtei, consulted with Dartmouth's chief of Infectious Disease, Dr. Ford von Reyn, who happened to be in Dar that week on a site visit. Neither physician could determine the basis for her symptoms. Dr. Mtei returned to the exam room once more and this time emerged with the answer: Fatuma had just learned that her three year old daughter was HIV-infected, likely contracted from Fatuma during or shortly after she gave birth to her daughter. Fatuma believed that her HIV diagnosis was a death sentence for her daughter since antiretroviral therapy was not widely available for children.Dr. von Reyn, Dartmouth's lead clinical researcher in Africa and a father, knew too well the harsh reality of inequities in a resource-limited country. He turned to Dr. Mtei and said decidedly, "we need to do something about this."Thus the DARDAR Pediatric Program was born.Pediatric HIV: A Neglected DiseaseThe need for HIV treatment among children in Tanzania, as in most of sub-Saharan Africa, is compelling. At the end of 2009, approximately 160,000 children aged zero to fourteen in Tanzania were living with HIV (Joint United Nations Programme on HIV/AIDS [UNAIDS], 2011). Even with successful roll out of prevention of mother to child transmission programs in Tanzania, there were nearly 29,000 perinatal infections in 2009. As of December 2010, only 18% of these were enrolled in HIV treatment programs (UNAIDS, 2011; World Health Organization [WHO], 2011). Without antiretroviral therapy (ART), one-half of HIV-infected children will die before their second birthday. Since clinical research to determine efficacy and safety of new medical treatments is conducted almost exclusively in adults, provision of new medical treatments to [End Page 75] children always lags behind advances for adults. Furthermore, children are often underrepresented in programs for antiretroviral drugs for the following reasons: 1) they are not prioritized for care; 2) facilities lack infant diagnostic capabilities; 3) there is limited pediatric HIV training and consequently, a shortage of pediatric providers; and 4) pediatric antiretroviral formulations are frequently unavailable. The unacceptable delays in pediatric HIV drug development and treatment access led the international organization Drugs for Neglected Diseases initiative to publish an editorial in which they referred to pediatric HIV as a "neglected disease" (Lallemant, Chang, Cohen, & Pecoul, 2011).The Tip of the Iceberg: More than Just MedicinesWith a grant from the New York-based Foundation for the Treatment of Children with AIDS, the DARDAR Pediatric Program, a joint collaboration between Geisel School of Medicine at Dartmouth and Muhimbili University of Health and Allied Sciences, began seeing patients in May 2006. It was the first dedicated pediatric HIV Care and Treatment Center in Tanzania and operates in accordance with Tanzania's National AIDS Control Programme's guidance. Testing for both children and infants (the latter of which requires a more sophisticated assay) is available.The day the clinic opened we celebrated this collaborative effort that would provide HIV-infected children in Dar es Salaam access to antiretroviral treatment. One of our first patients was a six-year-old boy whose mother, like Fatuma, was a participant in our TB vaccine trial. She had been advised to bring her son to us for HIV screening. Her son looked healthy so she was surprised and understandably distraught when his test results indicated that not only was he HIV-infected, but his CD4 percentage was very low. His mother was reluctant to have him started on antiretrovirals given his general appearance and young age—and that he was... (shrink)

Purpose. Reconstruction of Empedocles’ doctrine from the point of view of philosophical anthropology. Theoretical basis. Methodological basis of the article is the anthropological comprehending of Empedocles’ text fragments presented in the historical-philosophical context. Originality. Cognition of nature in Ancient Greece was far from the ideal of the objective knowledge formed in modern times, cognition of the world as it exists before man and independently of him. Whatever the ancient philosophers talked about, man was always in the center of their attention. (...) I proposed an anthropological version of the interpretation of the doctrine of Empedocles, within the framework of which various elements of his concept fit into a consistent model. Conclusions. Empedocles’ anthropology is based on the recognition of several fundamental things. First of all, there is no death. Second, there is no fundamental difference between human and celestial. This line is conventional and under certain conditions one can overcome it. Cod can become a human, and a human can become God. Teaching of evolution is also double. Not only physical shell evolves, keeping only the most adapted species, but the soul too. The latter can both ascend to the gods and go down to the bushes and fish. Purification of the soul and mastering the magic of the elements gives an impetus for a correct direction of evolution. Empedocles is an anthropologist-practitioner, who shows by his example that a human can cope with all the elements and reach divinity. He chose the elemental ingredients for penetrating the Fortunate Isles, leaving the instructions on how to become God. (shrink)

Книга представляет собой исследование, где предпринимается попытка на основе детальной проработки первоисточников и воспроизведения основных ходов мысли и интуиций Гегеля и позднего Шеллинга провести сравнительный анализ их учений об абсолюте.

La historia de la filosofía interpreta a Descartes desde la perspectiva del subjetivismo o solipsismo. De dónde procede tal interpretación y su plausibilidad desde los propios escritos de Descartes, son las dos cuestiones que trata de resolver este artículo. Para ello se ofrecen las lecturas de Hegel, Husserl y Heidegger. Como conclusión se muestra que la interpretación de Heidegger ha eclipsado otros puntos de vista.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:A Cascading Waterfall of NectarFrancis V. TisoA Cascading Waterfall of Nectar. By Thinley Norbu. Boston: Shambhala, 2006. 312 pp.It is important to make a number of things clear about the work under review before proceeding to a discussion of the parts of the book that bear directly on Buddhist-Christian relations. In the first place, the reader should know the identity of the author, Thinley Norbu. In order to (...) make absolutely clear who the author is, there are no less than four forewords to the book by His Holiness Penor Rinpoche (head of the Nyingmapa school of Tibetan Buddhism), Kathog Rigdzin Pema Wangchen Rinpoche (a prominent Nyingmapa lama), Alak Zenkar Rinpoche (another prominent Nyingmapa lama), and Tulku Thondup Rinpoche (a well-known Nyingmapa lama who has authored several valuable volumes on Vajrayāna Buddhism). Thinley Norbu is the son of the late head of the Nyingmapa school, H. H. Dudjom Rinpoche; like his father, Thinley Norbu is a very highly regarded lama with a wide following of disciples both in the Tibetan exile community and in the wider world community of Buddhist practitioners. The purpose of this book is to provide a working commentary on the Dudjom Tersar Ngondro, a well-known set of preliminary practices promulgated by Dudjom Lingpa (1835–1904), a “treasure revealer” (terton) in Eastern Tibet. This particular form of what are termed the “extraordinary preliminary practices” in the Vajrayāna has been transmitted to a large number of Nyingmapa school practitioners in recent decades. It has become so widespread that it is not unusual for photocopies of the prayers and practices to be given out to interested individuals without any particular initiation or other formality. I myself have [End Page 191] received the text a number of times, both as a formal practice from highly respected Tibetan teachers and in this very informal way from my personal friends among Nyingmapa monastics. Perhaps in response to the wide diffusion of this particular set of Vajrayāna practices, the author of this commentary wishes to clarify the unique features of the system revealed by the terton Dudjom Lingpa and widely taught by his own revered father, Dudjom Rinpoche (1904–1988). I would have to say that the parts of the book that comment on the practices (there is also a commentary on a related tantric visualization) are very well written and should be of great inspiration to those who have undertaken the arduous path of practice in this tradition.On the other hand, the author makes the commentary an occasion for discussing other concerns related to the relationship of Buddhism to other religions, to empirical science, and to the modern world. In these portions of the text, he continues in a polemical vein going back to his very troubling book Welcoming Flowers from Across the Cleansed Threshold of Hope: An Answer to the Pope’s Criticism of Buddhism, published in 1997.1 It is quite clear to careful readers of Pope John Paul II’s book Crossing the Threshold of Hope (New York, 1994) that there was no intention in that book for the Pope to give out a “final word” on any particular subject, much less to make infallible pronouncements on “faith and morals.” Rather, the book is to be taken as the sincere reflections of the Pope on a number of subjects that come up in both the Church and the world. As such, John Paul II’s book is a collection of essays reflecting a series of interviews with the Italian journalist Vittorio Messori, whose outspoken political and religious views are well known. The chapter on the Buddha caused a great deal of consternation in interreligious circles because the vocabulary employed seemed to imply a very negative assessment of Buddhism as a religion. However, it is also clear from certain comments in that chapter that the Pope is thinking critically about Buddhist teachings on salvation, a topic fundamental to any Christian theological engagement with other world religions.The fact that the terminology used by the Pope is imprecise unfortunately reflects the state of general knowledge about Buddhism in the secular and Christian world. As a direct consequence of that lack... (shrink)

By 1910 the Cambridge University physiology department had become the kernel of British physiology. Between 1909 and 1914 an astonishing number of young and talented scientists passed through the laboratory. The University College department was also a stimulating place of study under the dynamic leadership of Ernest Starling.I have argued that the reasons for this metropolitan axis within British physiology lie with the social structure of late-Victorian and Edwardian higher education. Cambridge, Oxford, and University College London were national institutions attracting (...) students from all over England and Wales. In contrast, the provincial colleges drew their clientele from relatively narrow geographic radii. Generally, also, these institutions were regarded as socially inferior to the longer-established universities.A brief survey of the biographies of some British physiologists demonstrates how physiology, as an occupation, became, over the later decades of the century, socially elite. The scientists who achieved full-time posts in the 1870s generally came from somewhat marginal backgrounds. Foster, like his mentors T. H. Huxley and William Sharpey, came from a non-conformist family. Edward Schäfer was also a dissenter and, like Foster, began his professional career as a general practitioner.Physiologists of the succeeding generation, however, came from wealthy families with established intellectual traditions. John Scott Haldane, nephew of John Burdon Sanderson, was the brother of the politician R. B. Haldane and uncle of the historian A. R. B. Haldane.71 Joseph Barcroft was one of the most affluent of all physiologists.72 His family's wealth derived from linen manufacturing. He attended the Ley's School Cambridge, where his schoolmates included Henry Dale, later Director of the National Institute for Medical Research; F. A. Bainbridge, who eventually became Professor of Physiology at St. Bartholomew's Hospital; and the Cambridge historian J. H. Clapham. A. V. Hill, Professor of Physiology at Manchester and, subsequently, London, married Margaret Keynes, sister of John Maynard Keynes and niece of Sir Walter Langdon Brown, Professor of Physic at Cambridge. Margaret Keynes's younger brother, the surgeon Sir Geoffrey Keynes, married a granddaughter of Charles Darwin; their son Richard Keynes also became a physiologist at Cambridge.These families were part of a new class emerging during the late Victorian period, descendants of the great reforming radicals of the 1830s, who had begun to achieve power through positions in the universities, the professions, and the civil service. Their social prestige rested upon their intellectual expertise. Physiology was an appealing research discipline to these groups because of its clear dissociation from industry and commerce. And because physiology's “practical” face was medicine, its acceptability was reinforced by professional ties.The nature of the Physiological Society confirms this image of physiology as an elite science. By the turn of the century the Society had taken on some of the characteristics of a dining club. The scientific meetings were generally followed by dinner: if the Society met at Oxford, they were entertained at Burdon Sanderson's college, Magdalen.73 Through a “black ball” system, unwanted candidates could be excluded. In 1912, when the question of admitting foreigners was discussed, E. H. Starling wrote to Edward Schäfer: “the Society has very much in it the nature of a club, and a certain amount of personal knowledge of the candidate is always desirable.”74.The developing institutional structure of physiology in late Victorian Britain indicates, therefore, that we must look beyond the achievements of individuals and departments to understand why physiology flourished. The discipline became part of a new social order in which the professional middle classes assumed increasing power. These groups valued intellectual skill, especially in the pure scienes, as forces both for self-advancement and for progress within society. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Apostolic Letter of Our Most Holy Father PAUL VI, by Divine Providence, POPE to Our Venerable Brethren, Cardinal John Carmel Heenan, Archbishop of Westminster, and Gordon Joseph Gray, Archbishop of Saint Andrews and Edinburgh and to the other Archbishops and Bishops of England, Wales and Scotland. On the Occasion of the Second Scholastic Congress held at Oxford and Edinburgh on the Seventh Centenary of the Birth of John Duns (...) Scotus. Venerable Brethren, Greetings and Apostolic Blessing: A devoted mother of valiant men, Great Britain is distinguished by a quality no less estimable than the honour and the feats of her glorious children, for she knows how to cherish fondly the memory of her glorious sons and, when tradition demands that recurrences be celebrated solemnly, she knows how to sing their praises as though striving to repay them a debt of honour. These were the thoughts that sprang to our mind, and gave no slight satisfaction as we dwelt upon them, when we first learned the details of the Second International Scholastic Congress which is being prepared in your countries in memory of the Venerable John Duns Scotus on the seven hundredth anniversary of his birth. This Congress will be held at Oxford and Edinburgh under your patronage, Venerable Brethren, with lively interest and careful organization. One can already foresee that it will produce excellent results and will be of considerable importance, in view both of the arguments that will be discussed and of the distinguished persons who will take part in the sessions. Universities of England and Scotland and, from abroad, the universities of Paris and Cologne where he lectured, and many others, will send official representatives; apart from Catholics, there will be outstanding members of the Anglican Communion, of the Church of Scotland, of other Christian Communities of Great Britain, and well known exponents of sacred learning from every part of the world. As We voice our wishes for a successful Congress and abundant fruits to follow from it, we express frankly our satisfaction at the particular character of this Congress and certain features with which it is intended to distinguish it. Its principal and definite purpose is to shed 6 POPE PAUL VI. a brilliant light on the person of John Duns Scotus, on his philosophical and theological doctrine, and his moral and ascetic principles. Avoiding the reefs of discussion and controversy which so often stood in the way in times gone by, the critico-historical method has been adopted in accordance with modern preferences, a method which, employed by learned men in discovering which are the genuine works of the Subtle Doctor and what are really and truly his teachings, has yielded excellent results. For this reason combined efforts are being made to produce the broad outline of a panorama, namely a unified vision of the whole family of the Scholastic doctors, in which it will be possible to measure and understand the variety, the richness, and the fecundity of the philosophical and theological doctrine which flourished in the Middle Ages. There is no doubt that in this panorama Saint Thomas Aquinas with his "Summa theologica" rises like a lofty peak dominating the mountains in the vicinity, that is, the whole world of sacred learning developed during his time. The synthesis created bythe Angelic Doctor in describing the relationship between Faith and Reason, between Faith seeking understanding (as your own Saint Anselm of Canterbury had already expressed it1) and understanding seeking Faith, achieved such universal agreement that he is recognised as leader in the ranks of the Scholastics and is rightly celebrated by the name of Doctor Communis. Side by side with him, however, other prominent Scholastic teachers and doctors stand out, like stars illuminating the Catholic learning of the period. In the encyclical letter Aeterni Patris, in which Our Predecessor of happy memory, Pope Leo XIII, pleads for the revival of Scholasticism under the leadership of Saint Thomas Aquinas in opposition to modern errors, after the statement that "Saint Thomas towers above all others",2 other Scholastic doctors are enumerated and a prominent place is reserved for Saint Bonaventure, whom Saint Pius X afterwards called "the second leader of Scholasticism",3 and it is universally recognised... (shrink)

Of the early Roman historians who wrote in Greek, A. Postumius Albinus was not necessarily alone in realizing that his Greek was not the best Greek; while, on the other hand, Cato and those who followed the new fashion of writing in Latin would have resented, we may assume, could they have foreknown, the statement of Q,. Catulus in Cicero's De Oratore that they had no literary or rather ‘oratorical’ merit; though Cato might have approved Catulus' caustic comment on Roman (...) historical writing, ‘Satis est non esse mendacem’. That an historian should not, consciously and deliberately, lie all second-century historians would no doubt have agreed; and they would have endorsed Polybius' condemnation of masquerading as history in a story whose falseness was self-evident, because it assumed, on the part of the young sons of senators at Rome, a gravitas such as no young boy could possibly possess. (shrink)

El control efectivo de la calidad y seguridad de los ali­mentos requiere de métodos analíticos que garanticen la deter­minación fiable de cualquier sustancia potencialmente perjudicial para el consumidor que pueda estar presente en el alimento antes de su distribución y comercialización. Una de las aproximaciones analíticas que contribuye a garantizar este objetivo engloba una serie de técnicas que tienen en común la utilización de anticuerpos como elementos esenciales para la detección del analito diana, y que en conjunto reciben el nombre (...) de métodos inmunoquímicos. Este artículo pretender aportar una visión básica de los principios bioquímicos subyacentes a estas tecnologías y cuáles son sus venta­jas y limitaciones en la determinación de contaminantes químicos, residuos y aditivos en matrices alimentarias. En la última parte se comentan algunas de nuestras iniciativas en este ámbito que han dado lugar a kits rápidos disponibles comercialmente tras haber transferido la tecnología correspondiente al sector industrial. (shrink)

The development of T cells and B cells from pluripotent hematopoietic precursors occurs through a stepwise narrowing of developmental potential that ends in lineage commitment. During this process, lineage-specific genes are activated asynchronously, and lineage-inappropriate genes, although initially expressed, are asynchronously turned off. These complex gene expression events are the outcome of the changes in expression of multiple transcription factors with partially overlapping roles in early lymphocyte and myeloid cell development. Key transcription factors promoting B-cell development and candidates for this (...) role in T-cell development are discussed in terms of their possible modes of action in fate determination. We discuss how a robust, stable, cell-type–specific gene expression pattern may be established in part by the interplay between endogenous transcription factors and signals transduced by cytokine receptors, and in part by the network of effects of particular transcription factors on each other. BioEssays 21:726–742, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

La philosophie politique est une discipline théorique unique en ce qu'elle présuppose et dépend à la fois de la philosophie spéculative et pratique. Elle ouvre aussi les portes à des questions dont s'occupe la révélation à sa manière - questions sur l'amitié avec Dieu, les limites de la justice, la destinée des individus. Le Christ et Socrate ont été tués dans des cités relativement justes. Ce fait même pose naturellement et nécessairement la question de savoir s'il doit en être ainsi, (...) s'il existe un conflit intérieur entre la philosophie ou la révélation et la cité. La philosophie politique est différente parce qu'elle contient dans les lignes générales de son propre propos des questions d'économie, de politique, de métaphysique, et finalement de révélation. (shrink)

Though Joseph Nadler published the definitive, critical edition of Hamanns' complete works, the hermetic character of these texts warrants only too strongly a publication of at least the major texts with commentaries. The annotated edition is planned to comprise eight volumes. From the viewpoint of the history of ideas, Vol. IV is undoubtedly the most interesting, since it contains the important texts on the origin of language. These were directly provoked by Herder's famous Abhandlung über den Ursprung der Sprache; "the (...) Magician of the North" fights the spirit of the Aufklärung even when it is clothed in the more attractive, pre-romantic setting of Herder's prose. Besides a fantastic amount of notes and commentary, Miss Büchsel, the editor of Vol. IV, offers a comprehensive and penetrating introductory study. Especially important are the chapters on the "pre-history" of Hamanns' Herder-interpretation and its influence on the later development of German intellectual life from the early Goethe to the old Schelling Vol. V contains the so-called mystery-writings directly pertinent to the Christian doctrine of the revelation of the Incarnated Son of God. These texts are truly esoteric, and even the multitude of notes accompanying them cannot always fully overcome their terrible obscurity. And here arises the only objection against this edition. The notes and commentaries are a mine of detailed information, and they "unconceal" the meaning of every word. Yet perhaps their very abundance impedes their stated purpose. They do help in understanding the words, but they make sustained reading of the texts themselves impossible. The encyclopedical character of the notes is cause for both exasperation and for growth in knowledge and inspiration.—M. J. V. (shrink)

Cet article explore le potentiel non-institutionnel du concept de communauté tel qu'il a été formulé dans la philosophie française contemporaine. Une attention particulière est accordée à l'expérience historique, particulièrement dans un monde en voie de globalisation. Les fantasmes de l'historique qui témoignent d'une telle expérience sont estimés constitutifs d'une communauté anonyme qui n'est définie ni par une identité fixe ni par une substance donnée. En dépit de son anonymat, la communauté exige d'être exprimée et traduite, en produisant, pour reprendre le (...) terme kantien, diverses "présentations comme-si.". (shrink)

Cet article explore le potentiel non-institutionnel du concept de communauté tel qu'il a été formulé dans la philosophie française contemporaine. Une attention particulière est accordée à l'expérience historique, particulièrement dans un monde en voie de globalisation. Les fantasmes de l'historique qui témoignent d'une telle expérience sont estimés constitutifs d'une communauté anonyme qui n'est définie ni par une identité fixe ni par une substance donnée. En dépit de son anonymat, la communauté exige d'être exprimée et traduite, en produisant, pour reprendre le (...) terme kantien, diverses "présentations comme-si.". (shrink)

Philippe de Mézières est un de ces auteurs du XIVe siècle que l’on estime et étudie volontiers. C’est qu’il est témoin oculaire et participant de bien des hauts moments de l’histoire. Né vers 1327 dans la famille de Mézières, de petite noblesse picarde , il reçoit une formation spirituelle chez les chanoines de la cathédrale d’Amiens. En 1345 il quitte son pays natal et l’année suivante gagne ses éperons de chevalier après la croisade de Humbert II de Dauphiné en Smyrne. (...) Par la suite, il joue plusieurs rôles saillants: nommé en 1361 chancelier de Chypre sous les Lusignan ; ami de Pétrarque; familier de Grégoire XI à Avignon; apologiste des croisades; ami et conseiller de Charles V de France et précepteur du dauphin, le futur Charles VI; écrivain laïque parmi les Célestins de Paris entre 1380 et 1405. Presque octogénaire, Mézières y meurt le 29 mai 1405, et est accordé la distinction d’être enveloppé du manteau de l’ordre à son enterrement. C’est à cette période de retraite que remontent ses écrits importants, tous de caractère religieux et rédigés en latin ou en français. (shrink)

In the mammalian central nervous system (CNS), each neuron receives signals from other neurons through numerous synapses located on its cell body and dendrites. Molecules involved in the postsynaptic signaling pathways need to be targeted to the appropriate subcellular domains at the right time during both synaptogenesis and the maintenance of synaptic functions. The presence of messenger RNAs (mRNAs) in dendrites offers a mechanism for synthesizing the appropriate molecules at the right place in response to local extracellular stimuli. Several dendritic (...) mRNAs have been identified, and the mechanisms controlling their localization are beginning to be understood. In many cell types, controls on mRNA stability play an important role in the regulation of gene expression, but it is unclear to what extent this type of control operates in dendrites. The regulation of protein synthesis and the control of mRNA stability in dendrites could have important implications for neuronal function. BioEssays 20:70–78, 1998. © 1998 John Wiley & Sons, Inc. (shrink)

Although the Bcl‐2 family members and p53 are involved in the regulation of apoptosis, the status of apoptotic machinery (eg caspases) plays a major role in determining the mode and timing of cell death. If the apoptotic machinery is lost, inhibited, or intrinsically inactivated, the “death stars”, Bcl‐2 and p53, may become irrelevant to cell death. In this light, high levels of Bcl‐2 may indicate that downstream apoptotic pathways are still functional. This explains why Bcl‐2 overexpression can be a marker (...) of chemosensitivity and favorable prognosis in certain cancers and why retention of wild‐type p53 may manifest inactivation of caspases in aggressive cancers. BioEssays 23:947–953, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Tom 1. Ontologii︠a︡, gnoseologii︠a︡ i metodologii︠a︡ nauki, logika -- t. 2. Sot︠s︡ialʹnai︠a︡ filosofii︠a︡ i filosofii︠a︡ politiki -- t. 3. Filosofskai︠a︡ antropologii︠a︡ i filosofii︠a︡ kulʹtury -- t. 4. Filosofii︠a︡ dukhovnosti, obrazovanii︠a︡, religii.

The article presents the main stages of the N.O. Lossky's work on the book "History of Russian Philosophy", starting with the emergence of his interest in the works of Russian philosophers when writing an article for the journal "The Slavonic Review" about Vladimir Solovyov and his followers; preparing lecture courses on Russian philosophy for reading at foreign universities and ending with the publication of the book in the USA, England and France and his work on the future Russian edition. Particular (...) attention is paid to the debate that arose after the publication of the book in America in the 50s and unfolds on the pages of American journals. The main claims of American critics to the content of the book are the uneven presentation of Russian philosophers teachings, the sketchiness and the absence of representatives of some schools of thought. N.O. Lossky's book also became the subject of discussion in the publications of the Russian migr about Lossky's author's vision statement of the development of Russian philosophy and its specifics. As it follows from the correspondence of N.O. Lossky with D.I. Chizhevsky and with publisher A.S. Kagan, it was also planned to publish the book with additions in Spanish and German publishing houses. Up to and including 1956, N.O. Lossky continued to work on the Russian-language "History of Russian Philosophy", which was given to Russia for publication by his son Boris Nikolaevich Lossky only in the early 90s. New materials found in the Paris archive of N.O. Lossky complement the debate both about N.O. Lossky's "History of Russian Philosophy", and about the nature of Russian philosophy. (shrink)